The French Reformation of 1524 was a significant time in the religious life of France. While the Reformation tended to begin earlier with Martin Luther's in Germany in 1517, its effects began spreading all over Europe, including France, in the 1520s.

By 1524, faith justification, scripture authority, and criticism of certain Catholic rituals had become established in France. The intellectual movement had some support among French scholars, clergy, and nobility, albeit opposed by the staunchly Catholic monarchy. Among the main figures linked with early French Reformation thought were Marguerite de Angoulême, the sister of King Francis I. Marguerite had learned reform ideas through her letters to religious leaders like William Briconnet, Bishop of Meaux. Briconnet exposed her to core Reformation ideas like the priority of faith as opposed to works. Marguerite's theological writings, such as her Mirror of the Sinful Soul, represented her theological reflections and reforming tendencies, even if she never irrevocably departed from the Catholic Church.

However, while Marguerite was intellectually curious about the Reformation, King Francis I was not entirely converted to it. The monarchy's biggest fear was preserving national unity and state power, which were inextricably bound up with Catholicism at the time. While Francis was fairly receptive to religious reform in intellectual circles initially especially in terms of theology, he hardened his stance as Protestantism grew. The spread of Lutheran teachings led to public debates, religious pamphlets, and growing disturbance by 1524. Protestant communities began small, and early French reformers translated and spread religious tracts, spreading Reformation principles across France. This, however, provoked a fierce reaction from Catholic authorities, who began suppressing dissent.

One of the more dramatic early incidents of the French Reformation was the Waldensian uprising in 1524. The Waldensians were an earlier pre-Reformation sect that had embraced Protestant principles. The French monarchy, suspicious of heretical activity, launched a ruthless campaign to destroy the Waldensians, initiating state persecution of Protestant sects. The French Reformation took hold in the 16th century, further fueling tensions between Catholics and Protestants. By the 1560s, tensions would spill over into the French Wars of Religion a series of bloody wars that dominated French religious and political life for decades. The events of 1524 laid the groundwork for the future religious reform, persecution, and resistance that would shape France's rocky path toward eventual religious tolerance.